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Updated: Jun 23, 2026

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
Published on: November 4, 2022
[Evaluation on in vitro release of Chinese medicinal compound sustained release preparations using multi-index
Qingfei Liu1, Yiming Wang, Guoan Luo
1Institute of Biomedicine, Tsinghua University, Beijing 100084, China. liuqf@mail.tsinghua.edu.cn
Objective:
To establish a method to evaluate the in vitro release of Chinese medicinal compound sustained release preparations using multi-index chromatographic fingerprint.
Method:
With the Chinese medicinal compound Jiangya sustained tablets as model preparation, the in vitro cumulative release of the main component flavones and fingerprint were determined by HPLC fingerprint. Aacacetin, rutin, luteolin, fingerprint were determined simultaneously and used to calculate the in vitro cumulative release of the tablets.
Result:
Aacacetin, rutin, luteolin, and the fingerprint had different cumulative release.
Conclusion:
Multi-index chromatographic fingerprint can reflect different content of multi components of preparations and can be used in the evaluation on in vitro release of the sustained release preparations of Chinese medicinal compound. The method is simple, rapid, and of multi information.
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