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Updated: Jun 23, 2026

Estimation of Urinary Nanocrystals in Humans using Calcium Fluorophore Labeling and Nanoparticle Tracking Analysis
Published on: February 9, 2021
[Effect of urinary pH value on the composition of urinary nanocrystals]
Xiao-Jing Xu1, Mu-Hua Wan, Jian-Ming Ouyang
1Institute of Biomineralization and Lithiasis Research, Jinan University, Guangzhou 510632, China.
Abstract:
The effect of urinary pH value on the composition of urinary nanocrystals was investigated by X-ray diffraction (XRD) and Fourier transform infrared (FTIR) spectroscopy. The differentiation of composition of urinary nanocrystals not only occurred between the people with different urinary pH, but also occurred in the same person when his or her urinary pH changed. At lower urinary pH (such as pH<5.8), most of the urinary components are uric acid, acidic phosphate, calcium oxalate etc. However, most of these components are urate, phosphate, magnesium ammonium phosphate, calcium oxalate etc at higher urinary pH (such as pH>6.2). Combining XRD and FTIR methods, t he compositions o f urinary nanocrystals can b edetermined accurately. It is helpful to exploring the cause of urinary stones.
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