[Problems of experimental simulation of hypo- and hyperthyroidism]

Area of Science:

• Endocrinology
• Animal Modeling

Context:

• Thyroid dysfunction, including hypothyroidism and hyperthyroidism, significantly impacts physiological function.
• Accurate experimental models are crucial for understanding thyroid pathophysiology and developing treatments.

Purpose:

• To review existing and novel experimental models for simulating hypo- and hyperthyroidism.
• To classify methods for modulating thyroid activity and diagnosing thyroid disorders.
• To evaluate new approaches for simulating diffuse toxic goiter in animal models.

Summary:

• The paper categorizes methods (physical, chemical, biological) used to modulate thyroid function in experimental settings.
• It outlines criteria for diagnosing hypothyroidism and hyperthyroidism, both during life and postmortem.
• Comparative analysis of advantages and limitations of various animal models, including new strategies for simulating diffuse toxic goiter, is presented.

Impact:

• Provides a comprehensive overview to guide researchers in selecting appropriate models for thyroid disorder studies.
• Facilitates the development of more accurate and relevant animal models for thyroid research.
• Aids in advancing the understanding and diagnosis of hypo- and hyperthyroidism through improved experimental methodologies.