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Updated: Jun 23, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
Published on: December 3, 2017
Resistant organisms in infected total knee arthroplasty: occurrence, prevention, and treatment regimens
Javad Parvizi1, Benjamin Bender, Khaled J Saleh
1Rothman Institute of Orthopedics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Abstract:
Infection of a primary joint arthroplasty can be a life-changing event for a patient. When the infecting organism demonstrates antibiotic resistance, treatment can be prolonged, and the chances for a successful outcome may be decreased. Antibiotic resistance has been an evolutionary process since the introduction of pharmacologic treatment and until recently has been more problematic with nosocomial types of infections. Methicillin-resistant Staphylococcus aureus skin infections within the community among school or sports teams has been a recent cause for concern. Hospitals have implemented screening and/or isolation procedures to reduce the risk of spreading these resistant organisms and identify patients colonized with resistant organisms. These measures have been successful in patients undergoing total joint arthroplasty. It is important for the orthopaedic surgeon to be knowledgeable about the emergence of resistant bacteria, preoperative and intraoperative screening guidelines, and postoperative considerations to prevent resistant organism infections in total joint arthroplasty patients.
Insights
Antibiotic resistance in joint arthroplasty infections poses significant challenges. Hospitals are successfully using screening and isolation to prevent resistant organism spread in total joint arthroplasty patients.
Area of Science:
- Orthopaedic Surgery
- Infectious Diseases
- Microbiology
Background:
- Joint arthroplasty infections can be devastating, especially with antibiotic-resistant organisms.
- Antibiotic resistance is an evolving challenge, increasingly seen in community-acquired infections like Methicillin-resistant Staphylococcus aureus (MRSA).
- Hospitals are implementing strategies to combat the spread of resistant bacteria.
Purpose of the Study:
- To highlight the importance of understanding antibiotic resistance in joint arthroplasty.
- To review current screening and management strategies for preventing resistant organism infections.
- To emphasize the need for orthopaedic surgeons to be informed about emerging resistant bacteria.
Main Methods:
- Review of current literature on antibiotic resistance in orthopaedic infections.
- Analysis of hospital screening and isolation protocols.
- Discussion of preoperative, intraoperative, and postoperative considerations.
Main Results:
- Screening and isolation procedures have proven effective in reducing resistant organism transmission in total joint arthroplasty.
- Knowledge of emerging resistant bacteria is crucial for successful patient outcomes.
- Proactive measures are essential to prevent and manage resistant infections.
Conclusions:
- Effective management of antibiotic-resistant organisms is vital for successful joint arthroplasty outcomes.
- Orthopaedic surgeons must stay updated on resistance trends and implement preventive strategies.
- Hospital-wide screening and isolation protocols are key to mitigating risks associated with resistant bacteria in arthroplasty patients.
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