From yellow rain to green wheat: 25 years of trichothecene biosynthesis research

Trichothecene biosynthesis research at the U.S. Department of Agriculture in Peoria, IL, began in 1984 in response to concerns about the use of trichothecenes in biological warfare, but continued as a long-term research program on the intractable problem of trichothecene contamination of human foods and animal feeds. Over 25 years, the trichothecene biosynthesis research group integrated natural product chemistry with fungal genetics and plant pathology in the laboratory and in the field to understand how and why Fusarium species make these complex and highly toxic metabolites. This interdisciplinary research placed trichothecenes in the unique class of fungal metabolites that not only cause mycotoxicoses in animals but also are virulence factors in plant disease.