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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Vacuum-assisted delivery is associated with late-onset asthma
L Keski-Nisula1,2, M Harju2, M-R Järvelin3,4
1Environmental Health Department, National Institute for Health and Welfare, Kuopio, Finland.
Allergy
|April 24, 2009
Summary
Vacuum extraction delivery increased the risk of developing asthma, particularly late-onset asthma, in children. This perinatal factor may influence long-term respiratory health outcomes.
Area of Science:
- Obstetrics and Gynecology
- Pediatric Allergy and Immunology
- Epidemiology
Background:
- Perinatal factors during delivery may influence fetal immunological development.
- This development is potentially linked to later allergic diseases and asthma.
Purpose of the Study:
- To investigate the association between delivery method and the development of asthma and allergic diseases.
- To analyze the impact of perinatal factors on long-term respiratory health in children.
Main Methods:
- A cohort of 5823 children born in Northern Finland (1985-1986) was studied.
- Perinatal data and questionnaire data at ages 7 and 15-16 years were collected.
- Skin prick tests were performed at age 15-16 years; only vaginally delivered singletons were analyzed.
Main Results:
- Vacuum extraction delivery was associated with a higher prevalence of asthma (RR 1.80).
- The risk of late-onset asthma was significantly increased following vacuum extraction (RR 2.41).
- Perinatal effects showed less impact on other asthma, atopy, or hay fever development.
Conclusions:
- Delivery by vacuum extraction significantly impacts the development of late-onset asthma.
- This finding highlights a specific perinatal risk factor for childhood asthma.
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