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Related Experiment Videos

New insecticidal metabolites from soil isolate W719.

K Reddy1, G Jewett, R Fatig

  • 1Fermentation Products, DowElanco, Greenfield, IN 46140.

The Journal of Antibiotics
|September 1, 1991
PubMed
Summary

Soil microbes can yield new insecticidal compounds. Researchers discovered novel macrocyclic lactams from strain W719 effective against the tobacco budworm (Heliothis virescens), offering potential for new pest control strategies.

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Area of Science:

  • * Natural Product Chemistry
  • * Entomology
  • * Microbiology

Background:

  • * Soil microorganisms are a rich source of bioactive compounds.
  • * The tobacco budworm (Heliothis virescens) is a significant agricultural pest.
  • * Discovery of novel insecticides is crucial for pest management.

Purpose of the Study:

  • * To screen soil organisms for new insecticidal metabolites.
  • * To identify and characterize compounds active against Heliothis virescens.
  • * To evaluate the insecticidal properties of purified metabolites.

Main Methods:

  • * Screening of soil microbial isolates for insecticidal activity.
  • * Purification of active metabolites using solvent partitioning and chromatography.

Related Experiment Videos

  • * Determination of physico-chemical properties and molecular weights (MW) of key components.

    • Main Results:

    • * Strain W719 produced metabolites with activity against Heliothis virescens.
    • * Two major components were isolated and purified.
    • * These components have MWs of 925 and 939 and belong to the macrocyclic lactam family.

    Conclusions:

    • * Novel macrocyclic lactams with significant insecticidal activity were discovered.
    • * Strain W719 is a potential source for developing new pest control agents.
    • * These findings contribute to the search for effective and environmentally sound insecticides.