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Updated: Jun 23, 2026

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues
08:47

Induction of Experimental Autoimmune Encephalomyelitis in Mice and Evaluation of the Disease-dependent Distribution of Immune Cells in Various Tissues

Published on: May 8, 2016

Dry olive leaf extract ameliorates experimental autoimmune encephalomyelitis.

Djordje Miljković1, Dragana Dekanski, Zeljka Miljković

  • 1Institute for Biological Research Sinisa Stanković, Department of Immunology, University of Belgrade, Belgrade, Serbia. georgije_zw@yahoo.com

Clinical Nutrition (Edinburgh, Scotland)
|April 24, 2009
PubMed
Summary

Dry olive leaf extract (DOLE) significantly reduced the severity of experimental autoimmune encephalomyelitis (EAE) in rats. This suggests DOLE may be beneficial for neuroinflammatory disorders like multiple sclerosis.

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Area of Science:

  • Neuroscience
  • Immunology
  • Pharmacology

Background:

  • Experimental autoimmune encephalomyelitis (EAE) serves as a model for multiple sclerosis (MS).
  • The Mediterranean diet, rich in olive products, correlates with lower MS incidence in Southern Europe.

Purpose of the Study:

  • To investigate the impact of dry olive leaf extract (DOLE) on the course of EAE.
  • To assess DOLE's potential as a dietary supplement for neuroinflammatory conditions.

Main Methods:

  • EAE was induced in Dark Agouti rats using spinal cord homogenate and complete Freund's adjuvant.
  • DOLE was administered daily via intragastric gavage, starting on the day of immunization.
  • Interferon-gamma (IFN-γ) and Interleukin-17 (IL-17) gene expression and production were quantified using real-time PCR and ELISA.

Main Results:

  • DOLE administration led to reduced EAE severity, including lower cumulative disease index, maximal clinical score, and disease duration.
  • DOLE decreased the cellularity of draining lymph nodes.
  • A reduction in IFN-γ and IL-17 production by infiltrating cells in the spinal cord of EAE rats was observed.

Conclusions:

  • DOLE-enriched diets demonstrate a beneficial effect in a rat model of EAE.
  • Further human studies are warranted to explore DOLE's efficacy for multiple sclerosis and other neuroinflammatory disorders.