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Updated: Jun 23, 2026

Enhancing the Development and Growth of Infant Cerebral Palsy Rats Using Selective Spinal Manipulations

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Published on: February 2, 2024

Cerebral palsy update.

Ingeborg Krägeloh-Mann¹, Christine Cans

¹University Children's Hospital, Department of Paediatric Neurology and Developmental Medicine, Hoppe-Seyler-Str. 1, D-72076 Tübingen, Germany. ingeborg.kraegeloh-mann@med.uni-tuebingen.de

Brain & Development

|April 24, 2009

Summary

This summary is machine-generated.

Cerebral palsy (CP) rates initially rose with increased preterm infant survival but have since declined for most low birthweight infants. However, extremely preterm infants still show concerning, stable CP prevalence.

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Area of Science:

Neurology
Developmental Pediatrics
Public Health

Background:

Cerebral palsy (CP) prevalence is influenced by birth weight and gestational age.
Improved survival rates in preterm infants have impacted CP incidence.
A common language and database for CP surveillance exist in Europe.

Purpose of the Study:

To analyze CP prevalence across European registers.
To investigate trends in CP rates related to birth weight and prematurity.
To explore the relationship between brain lesions, CP subtypes, and associated disabilities.

Main Methods:

Utilized a common language and database developed by the Surveillance of Cerebral Palsy in Europe (SCPE).
Conducted prevalence analyses on a large European dataset.
Examined the impact of birth weight and immaturity on CP rates over time.

Main Results:

CP prevalence increases with lower birth weight and higher immaturity.
Increased survival of preterm infants initially raised CP rates, but this trend reversed for LBW and VLBW infants in the 1980s and 1990s.
CP prevalence in extremely LBW or immature infants remains high and stable, a significant concern.

Conclusions:

CP is primarily caused by brain lesions or maldevelopment during critical periods of brain growth.
Brain lesion extent and location dictate CP subtype and associated disabilities.
The developing brain, particularly in language functions, shows some capacity for reorganization following injury, though this may impact other functions.