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Hyperthyroidism II: Pathophysiology

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Related Experiment Video

Updated: Jun 23, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

[Angiogenesis and thyroid cancer].

Zelia Francis¹, Eric Baudin, Sophie Leboulleux

¹Service de médecine nucléaire et d'oncologie endocrinienne, Paris-Sud et Institut Gustave Roussy, F-94805 Villejuif Cedex, France.

Presse Medicale (Paris, France : 1983)

|April 24, 2009

Summary

Novel kinase inhibitors targeting vascular endothelial growth factor (VEGF) receptors and MAPkinase pathways show promise for refractory thyroid cancers. These therapies offer partial response or long-term stabilization in over half of patients with differentiated and medullary thyroid cancers.

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An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma

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Published on: April 17, 2013

Area of Science:

Molecular biology
Oncology
Pharmacology

Context:

Significant advancements in understanding thyroid cancer molecular biology over the past two decades.
Development of targeted therapies for refractory thyroid cancer cases.

Purpose:

To review the role of kinase inhibitors in treating advanced thyroid cancers.
To highlight the efficacy of these inhibitors in differentiated and medullary thyroid cancer subtypes.

Summary:

Kinase inhibitors targeting vascular endothelial growth factor (VEGF) receptors and MAPkinase pathways are effective in thyroid cancer.
These agents inhibit angiogenesis and other key signaling pathways.
Over 50% of patients with differentiated and medullary thyroid cancers experience partial response or long-term stabilization.

Impact:

Provides a novel therapeutic strategy for patients with refractory thyroid cancer.
Improves treatment outcomes for differentiated and medullary thyroid cancer.
Offers hope for long-term disease control in advanced thyroid cancer patients.