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Acute Inflammation III: Local and Systemic Effects

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Hypertension II: Pathophysiology

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Related Experiment Video

Updated: Jun 23, 2026

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
09:29

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

Is higher sodium intake associated with elevated systemic inflammation? A population-based study.

Andrew W Fogarty1, Sarah A Lewis, Tricia M McKeever

  • 1Division of Epidemiology and Public Health, University of Nottingham, Clinical Sciences Building, City Hospital, Nottingham, United Kingdom. andrew.fogarty@nottingham.ac.uk

The American Journal of Clinical Nutrition
|April 24, 2009
PubMed
Summary
This summary is machine-generated.

Higher sodium intake showed a linear association with increased C-reactive protein (CRP), a marker of inflammation. However, this link was weakened after accounting for body mass index, suggesting sodium may not be a key modifiable risk factor for inflammation.

Related Experiment Videos

Last Updated: Jun 23, 2026

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
09:29

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

Area of Science:

  • Nutritional Epidemiology
  • Biochemistry
  • Public Health

Background:

  • Observational studies suggest low-sodium diets correlate with reduced mortality.
  • Systemic inflammation is a potential risk factor for cardiovascular disease and cancer.

Purpose of the Study:

  • To investigate the association between dietary sodium intake and systemic inflammation.
  • To test if higher sodium intake increases C-reactive protein (CRP) levels.

Main Methods:

  • Cross-sectional, population-based study of 2633 adults.
  • Measured 24-hour urinary sodium excretion and serum CRP in 1597 participants.
  • Analyzed associations adjusted for age, sex, smoking, and body mass index.

Main Results:

  • A positive linear association was observed between 24-hour sodium excretion and serum CRP levels.
  • This association attenuated after adjusting for body mass index (BMI).
  • The initial association indicated a 1.20 mg/L increase in CRP per 100-mmol sodium increment (adjusted for age, sex, smoking).

Conclusions:

  • A linear association exists between sodium intake and CRP, potentially confounded by BMI.
  • The findings suggest dietary sodium consumption is unlikely a major modifiable risk factor for systemic inflammation.