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Related Experiment Video

Updated: Jun 23, 2026

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats
10:41

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

Published on: November 7, 2017

Wireless neural stimulation in freely behaving small animals.

Scott K Arfin1, Michael A Long, Michale S Fee

  • 1Research Laboratory of Electronics, Department of Electrical Engineering and Computer Science, McGovern Institute for Brain Research, Massachusetts Institute of Technology, 38-294, 77 Massachusetts Ave., Cambridge, MA 02139, USA.

Journal of Neurophysiology
|April 24, 2009
PubMed
Summary

This study presents a new wireless neural stimulator for freely moving animals. The device effectively modulated brain activity and singing behavior in zebra finches.

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Area of Science:

  • Neuroscience
  • Bioengineering
  • Animal Behavior

Background:

  • Neural stimulation is crucial for understanding brain function.
  • Existing methods often tether animals, limiting natural behavior.
  • Need for wireless, low-power systems for freely behaving subjects.

Purpose of the Study:

  • Introduce a novel wireless, low-power neural stimulation system.
  • Evaluate its efficacy in modulating neural circuits and behavior in freely behaving animals.
  • Demonstrate remote control of neural activity and behavior.

Main Methods:

  • Developed a wireless system with an external transmitter and implantable receiver-stimulator.
  • Utilized a custom integrated chip for biphasic current pulses to addressable electrodes.

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Last Updated: Jun 23, 2026

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats
10:41

A Wireless, Bidirectional Interface for In Vivo Recording and Stimulation of Neural Activity in Freely Behaving Rats

Published on: November 7, 2017

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
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In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

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  • Implanted electrodes into the HVC (high vocal center) motor nucleus of zebra finches.
  • Performed single-neuron recordings and behavioral observations during singing.

    • Main Results:

    • Wireless stimulation of HVC significantly increased spiking activity in downstream targets.
    • Random stimulation during singing prematurely terminated vocalizations in all tested birds.
    • The system demonstrated effective remote modulation of a neural circuit and behavior.

    Conclusions:

    • The developed wireless neural stimulation system is effective for untethered, freely behaving animals.
    • This technology enables precise remote modulation of neural circuits and associated behaviors.
    • Offers a powerful tool for neuroscience research in naturalistic settings.