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Increased resistance in postobstructive pulmonary vasculopathy: structure-function relationships.

R P Michel1, T S Hakim

  • 1Department of Pathology, McGill University, Montreal, Quebec, Canada.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|August 1, 1991
PubMed
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Postobstructive pulmonary vasculopathy (POPV) involves abnormal blood vessel changes in the lungs. These morphological changes, including increased vessel thickness and new connections, explain the altered blood flow and reactivity observed in POPV.

Area of Science:

  • Pulmonary Medicine
  • Cardiovascular Physiology
  • Pathology

Background:

  • Postobstructive pulmonary vasculopathy (POPV) presents abnormal physiological changes.
  • Previous studies using arterial and venous occlusion (AVO) highlighted these changes.

Purpose of the Study:

  • To elucidate the morphological basis of abnormal physiological changes in POPV.
  • To compare the histology and ultrastructure of ligated and control lung lobes.

Main Methods:

  • Chronic ligation of the left main pulmonary artery in seven dogs.
  • Light microscopy, morphometry, and ultrastructural analysis of lung lobes.
  • Comparison of ligated left lower lobes with contralateral control right lower lobes.

Main Results:

Related Experiment Videos

  • Proliferation of bronchial vessels and formation of bronchopulmonary anastomoses.
  • Pulmonary arteries showed increased medial muscle thickness, peripheral muscularization, and intimal thickening.
  • Ultrastructure revealed new intimal cells and myoendothelial junctions in POPV arteries.

Conclusions:

  • Hemodynamic alterations in POPV are primarily linked to morphological abnormalities.
  • The study provides a relevant model for investigating bronchopulmonary vascular interactions.
  • Morphological changes explain increased arterial resistance and vascular hyperreactivity in POPV.