Related Experiment Videos
Pressure-induced striatal dopamine release correlates hyperlocomotor activity in rats exposed to high pressure
1Laboratoire de Biologie des Hautes Pressions, Faculté de Médecine Nord, Centre National de la Recherche Scientifique, Unité de Recherche Associée-1330, Marseille, France.
Abstract:
Free-moving rats chronically implanted in the striatum with multifiber carbon electrodes selective to dopamine were compressed in a helium-oxygen mixture to 80 bars. Extracellular dopamine level and behavioral symptoms of high-pressure neurological syndrome were simultaneously recorded. Under these conditions, the extracellular level of dopamine monitored by differential pulse voltammetry was found to be pressure dependent, and hyperlocomotor activity, a behavioral symptom of high-pressure neurological syndrome, was found to be linked to these pressure-induced changes in dopamine release.