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Major hepatectomy induces phenotypic changes in circulating dendritic cells and monocytes
Philip A Efron1, Tadashi Matsumoto, Priscilla F McAuliffe
1Department of Surgery, University of Florida College of Medicine, Shands Hospital, Box 100286, Gainesville, FL 32610-0286, USA. Philip.Efron@surgery.ufl.edu
Journal of Clinical Immunology
|April 24, 2009
Summary
Major hepatectomy alters immune cells, increasing activated monocytes and dendritic cells while reducing monocyte HLA-DR expression. This immune modulation may increase infection risk in patients post-liver resection.
Area of Science:
- Immunology
- Surgical Oncology
- Transplant Surgery
Background:
- Major hepatectomy increases risks of post-operative complications, including infections.
- Immune system alterations following liver resection can predispose patients to infectious sequelae.
Purpose of the Study:
- To investigate changes in immune cell phenotype after major hepatectomy.
- To understand the impact of liver resection on innate immunity.
Main Methods:
- Peripheral blood samples collected from 15 hepatectomy patients pre- and post-surgery.
- Flow cytometry used to analyze monocytes and dendritic cells for quantity, phenotype, activation, HLA-DR, and TLR expression.
Main Results:
- Increased numbers of activated CD16(bright) monocytes and activated dendritic cells post-hepatectomy.
- Reduced human leukocyte antigen DR (HLA-DR) expression on monocytes.
- Observed changes suggest potential for dysfunctional antigen presentation and immune cell priming.
Conclusions:
- Major hepatectomy induces significant alterations in innate immune cell populations.
- Understanding these immune changes may lead to strategies for reducing post-operative infections.
