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Updated: Jun 23, 2026

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
A 50-year-old man with stage 2 sarcoidosis with pleural involvement
Ariel Modrykamien1, Andrea Arrossi, Anita Reddy
1Respiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland OH 44195, USA. modryka@ccf.org
Abstract:
We present a case of a 50-year-old man who presented with progressive shortness of breath, cough, chest pain, and weight loss. His computer tomography (CT) scan of the chest showed a left-sided pleural effusion, subpleural and peribronchovascular nodules, bilateral hilar and mediastinal lymphadenopaties. Traasbronchial biopsies of the lung parenchyma and Video-Assisted Thoracoscopic Surgery (VATS) with pleural biopsies revealed the presence of noncaseating granulomas. A diagnosis of stage 2 sarcoidosis with pleural involvement was made and treatment with prednisone was started. The patient continued with persistent dyspnea and a left-sided pleural effusion. Steroid treatment was tapered and leflunomide therapy was initiated. A significant improvement of his clinical condition was seen after 1 month on treatment.
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