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Updated: Jun 23, 2026
08:02
Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
[Hypercortisolism and hemostasis]
Renata Swiatkowska-Stodulska1, Anna Babińska, Krzysztof Sworczak
1Medical University of Gdańsk, Department of Endocrinology and Internal Medicine, Poland. rensto@amg.gda.pl
Summary
Glucocorticoids significantly impact hemostasis, increasing thromboembolic risk in hypercortisolism. This review details hemostatic disturbances, metabolic changes, and discusses anticoagulant prophylaxis strategies.
Area of Science:
- Endocrinology
- Hematology
- Metabolic Disorders
Context:
- Endocrinopathies frequently alter coagulation and fibrinolysis.
- Glucocorticoids exert a significant influence on hemostasis.
- Hypercortisolism, both endogenous and exogenous, is linked to increased thromboembolic events.
Purpose:
- To review hemostatic disturbances in hypercortisolism.
- To emphasize the role of metabolic changes, endothelial damage, pro-inflammatory cytokines, and hyperhomocysteinemia in these disturbances.
- To discuss anticoagulant prophylaxis in patients with hypercortisolism.
Summary:
- Glucocorticoids critically affect hemostasis, elevating the risk of thromboembolic incidents in conditions like Cushing's syndrome or during corticosteroid therapy.
- The development of these hemostatic disturbances is multifactorial, involving metabolic alterations, endothelial dysfunction, inflammatory processes, and elevated homocysteine levels.
- Understanding these mechanisms is crucial for managing hypercortisolism and preventing thrombotic complications, including appropriate anticoagulant prophylaxis.
Impact:
- Provides a comprehensive overview of coagulation and fibrinolysis alterations in hypercortisolism.
- Highlights key contributing factors to thrombotic risk in these patients.
- Informs clinical practice regarding the management and prevention of thromboembolic events in endocrine disorders involving glucocorticoid excess.
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