Related Experiment Video
Updated: Jun 23, 2026

Vascularized Composite Upper Limb Allograft Harvesting for Proximal Arm Allotransplantation
Published on: June 13, 2025
Melorheostosis in the upper extremity.
Cengiz Yildirim1, Selahattin Ozyürek, Engin Ilker Ciçek
1Orthopedics and Traumatology, Ankara Mevki Military Hospital, Diskapi, Ankara, Turkey.
Melorheostosis, a rare bone disorder, caused significant sclerotic changes in a young man's right upper extremity. Imaging confirmed the "dripping candle wax" appearance, leading to a conservative management approach.
Area of Science:
- Orthopedics
- Radiology
- Medical Imaging
Background:
- Melorheostosis is a rare mesodermal disease characterized by flowing hyperostosis, often incidentally found on radiographs.
- The condition affects the skeleton and adjacent soft tissues, typically presenting with a 'dripping candle wax' radiographic appearance.
Observation:
- A 22-year-old male presented with a two-year history of right-hand pain.
- Radiographic and CT imaging revealed extensive sclerotic changes in the right upper extremity, including metacarpals, phalanges, scapula, humerus, radius, and scaphoid.
- A characteristic 'dripping candle wax' appearance was noted on CT scans.
Findings:
- Radionuclide bone scintigraphy demonstrated diffuse radiotracer uptake throughout the affected right upper extremity.
- Diagnosis of melorheostosis was confirmed based on characteristic imaging features and distribution.
- Conservative management was initiated for the patient.
Implications:
- The case highlights the diagnostic utility of combined radiographic, CT, and bone scintigraphy in melorheostosis.
- Conservative treatment appears effective for managing symptoms in the long term.
- Further research into melorheostosis pathogenesis and treatment options is warranted.
Related Concept Videos
Bones of the Upper Limb: Humerus
Bones of the Upper Limb: Radius
The radius has a nail-shaped head, and a short...
Arteries of the Upper Limbs
Bones of the Upper Limb: Ulna
Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...