Self-assembly of chemically engineered hydrophilic dextran into microscopic tubules

Although macromolecular self-assemblies are mostly fabricated from amphiphilic copolymers, here we report a tubular structure self-assembled solely from hydrophilic dextran-derived homopolymers via electrostatic interaction. To obtain tubular structures, we prepared two oppositely charged dextran derivatives by incorporating 2-bromoethylamine (Dex-BH) and chloroacetic acid (Dex-CA) into dextran, and their structures were confirmed using Fourier transform infrared spectroscopy. The two oppositely charged dextran derivatives self-assembled into microsize tubules when mixed in a pH 4.0 buffer solution. The tubular self-assemblies were sensitive to both pH and salt concentrations. Scanning electron microscopy and light microscopy confirmed that the tubules have hollow structures up to 100 microm long with a diameter between 600 nm and 2 microm. The X-ray study did not reveal any ordered molecular organization. This paper explores the mechanism of the tubule self-assembly and suggests a model.