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Updated: Jun 23, 2026

A Modular Microfluidic Technology for Systematic Studies of Colloidal Semiconductor Nanocrystals
Published on: May 10, 2018
The preparation of colloidally stable, water-soluble, biocompatible, semiconductor nanocrystals with a small
Emma E Lees1, Tich-Lam Nguyen, Andrew H A Clayton
1School of Chemistry and Bio21 Institute, University of Melbourne, Parkville, VIC 3010, Australia.
Abstract:
We report a simple, economical method for generating water-soluble, biocompatible nanocrystals that are colloidally robust and have a small hydrodynamic diameter. The nanocrystal phase transfer technique utilizes a low molecular weight amphiphilic polymer that is formed via maleic anhydride coupling of poly(styrene-co-maleic anhydride) with either ethanolamine or Jeffamine M-1000 polyetheramine. The polymer encapsulated water-soluble nanocrystals exhibit the same optical spectra as those formed initially in organic solvents, preserve photoluminescence intensities, are colloidally stable over a wide pH range (pH 3-13), have a small hydrodynamic diameter, and exhibit low levels of nonspecific binding to cells.
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