Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

Hedgehog Signaling Pathway

Hedgehog Signaling Pathway

The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

Gastrulation

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Synthesis, Characterization, and Application of a Novel Polystyrene-Supported Brønsted-Acidic Ionic Liquid as an Efficient and Reusable Catalyst in Microwave-Assisted Groebke-Blackburn-Bienaymé Multicomponent Reaction.

ACS omega·2026

Same author

<b>Nomenclature of vermetid anchoring bioerosion structures: making the names <i>Santichnus</i> and <i>Santichnus mayorali</i> available (Ichnofamily Renichnidae, trace fossils, bioerosion structures)</b>.

Zootaxa·2026

Same author

In-Culture Antibody Capture Using Transient CHO Expression Systems.

Bio-protocol·2026

Same author

Characterizing Longitudinal Melanonychia in Skin of Color.

JAMA dermatology·2026

Same author

Re-Thinking Pharmacokinetics in Ovarian Cancer: What Do Organoids Add?

International journal of molecular sciences·2026

Same author

Tracking Chemotherapy Effects via ALDH1A1, SOX2, CD44v6, and P-gp Expression in Malignant Ascites from High-Grade Serous Carcinoma.

Pathobiology : journal of immunopathology, molecular and cellular biology·2026

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Nuclear Migration in the Drosophila Oocyte

Nuclear Migration in the Drosophila Oocyte

Published on: May 13, 2021

Hedgehog does not guide migrating Drosophila germ cells.

Andrew D Renault¹, Sara Ricardo, Prabhat S Kunwar

¹HHMI and Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.

Developmental Biology

|April 25, 2009

Summary

Hedgehog (Hh) signaling does not directly guide germ cell migration in flies, contrary to previous research. This finding impacts our understanding of fertility and embryonic development signaling pathways.

More Related Videos

Upright Imaging of Drosophila Egg Chambers

Upright Imaging of Drosophila Egg Chambers

Published on: March 13, 2015

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

Related Experiment Videos

Last Updated: Jun 23, 2026

Nuclear Migration in the Drosophila Oocyte

Nuclear Migration in the Drosophila Oocyte

Published on: May 13, 2021

Upright Imaging of Drosophila Egg Chambers

Upright Imaging of Drosophila Egg Chambers

Published on: March 13, 2015

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Dissection and Immunostaining of Imaginal Discs from Drosophila melanogaster

Published on: September 20, 2014

Area of Science:

Developmental Biology
Cell Biology
Genetics

Background:

Germ cell migration is crucial for fertility in many species.
Lipid signals, specifically geranylgeranyl pyrophosphate synthesized via the Hmgcr pathway, are known attractants for germ cells in flies.
Previous studies suggested a role for Hedgehog (Hh) signaling in germ cell attraction, potentially modulated by the Hmgcr pathway.

Purpose of the Study:

To investigate the direct role of Hedgehog (Hh) signaling in guiding germ cell migration in flies.
To reconcile conflicting previous findings regarding Hh's function in germ cell guidance.

Main Methods:

Genetic analysis of signaling pathways involved in cell migration.
Repetition of critical experiments from previous studies.
Further targeted experiments to assess Hh's role in germ cell attraction.

Main Results:

The study found no evidence supporting a direct role for Hh signaling in the guidance of migrating germ cells in flies.
Results contrast with prior reports implicating Hh as a germ cell attractant.
Findings align with observations in zebrafish, suggesting conserved but distinct mechanisms.

Conclusions:

Hedgehog (Hh) signaling is not a direct attractant for migrating germ cells in flies.
The Hmgcr pathway's role in germ cell migration may operate independently of Hh signaling.
Further research is needed to elucidate the precise signaling mechanisms governing germ cell migration in flies.