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Published on: February 18, 2015
B-1 cells modulate oral tolerance in mice.
Luiz Antonio De-Gennaro1, Ana Flávia Popi, Sandro Rogério de Almeida
1Discipline of Immunology, Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, São Paulo, Brazil. gennaro@unifesp.br
Immunology Letters
|April 25, 2009
Summary
B-1 cells, a type of innate immune cell, are crucial for inducing oral tolerance. Transferring B-1 cells into B-1 cell-deficient mice restored their ability to develop tolerance to oral antigens like OVA.
Area of Science:
- Immunology
- Innate Immunity
- Oral Tolerance
Background:
- B-1 cells are innate immune cells known for producing natural IgM autoantibodies.
- They are abundant in the peritoneal cavity and contribute to IgA production in the gut.
- B-1 cells are implicated in peripheral tolerance, but their role in oral tolerance is unclear.
Purpose of the Study:
- To investigate the role of B-1 cells in the induction of oral tolerance.
- To determine if B-1 cells possess regulatory properties in the context of oral immunization.
Main Methods:
- Utilized BALB/Xid mice (B-1 cell deficient) and BALB/c mice (normal B-1 cell population).
- Administered ovalbumin (OVA) orally to induce tolerance.
- Adoptively transferred B-1 cells from BALB/c mice to BALB/Xid mice.
Main Results:
- BALB/Xid mice, lacking B-1 cells, failed to develop oral tolerance to OVA.
- Adoptive transfer of B-1 cells from BALB/c mice into BALB/Xid mice restored oral tolerance.
- Transferred B-1 cells suppressed hypersensitivity and lymphoproliferative responses in recipient mice.
Conclusions:
- B-1 cells are essential for inducing oral tolerance to antigens like OVA.
- These findings highlight the regulatory functions of B-1 cells in immune tolerance.
