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Related Concept Videos

Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...

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Related Experiment Video

Updated: Jun 23, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Cardiovascular proteomics: implications for clinical applications.

Florian S Schoenhoff1, Qin Fu, Jennifer E Van Eyk

  • 1The Johns Hopkins Bayview Proteomics Center, Division of Cardiology, Department of Medicine, Johns Hopkins University, 5200 Eastern Avenue, MFL Building, Suite 602, Baltimore, MD 21224, USA.

Clinics in Laboratory Medicine
|April 25, 2009
PubMed
Summary

Proteomics shows promise for cardiovascular disease diagnosis and therapy. However, translating these discoveries into clinical practice requires reproducible methods and close collaboration between researchers and clinicians for biomarker discovery.

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Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
14:02

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Published on: April 21, 2017

Related Experiment Videos

Last Updated: Jun 23, 2026

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve
09:13

Optimized Protocol for the Extraction of Proteins from the Human Mitral Valve

Published on: June 14, 2017

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry
14:02

Glycoproteomics of the Extracellular Matrix: A Method for Intact Glycopeptide Analysis Using Mass Spectrometry

Published on: April 21, 2017

Area of Science:

  • Cardiovascular Proteomics
  • Biomarker Discovery

Background:

  • Proteomics is increasingly impacting cardiovascular disease (CVD) diagnosis and therapy.
  • Advancements in proteomics analysis and high-throughput methods are driving interest in serum and plasma biomarker discovery for CVD.
  • Translating proteomics findings from research (bench) to clinical application (bedside) is a critical challenge.

Purpose of the Study:

  • To highlight the potential of proteomics in cardiovascular medicine.
  • To address the challenges in translating proteomics discoveries into clinical practice.
  • To emphasize the need for reproducible results and collaborative efforts in biomarker discovery.

Main Methods:

  • Streamlined de novo proteomics analysis.
  • Development of robust high-throughput methodologies.
  • Focus on serum and plasma biomarker discovery in cardiovascular disease.

Main Results:

  • The number of clinical biomarkers discovered through proteomics remains small despite technical advances.
  • Reproducibility in results is a significant hurdle in cardiovascular proteomics.
  • Collaboration between researchers and clinicians is identified as a key step for successful translation.

Conclusions:

  • Proteomics holds significant potential for advancing cardiovascular disease diagnosis and therapy.
  • Achieving reproducible results and establishing "translation teams" are crucial for clinical implementation.
  • Close collaboration between researchers and clinicians is essential to overcome current limitations in biomarker discovery.