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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...
Myasthenia Gravis: Overview and Treatment01:20

Myasthenia Gravis: Overview and Treatment

Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which leads...
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...

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Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

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Published on: February 20, 2020

Fatigue in multiple sclerosis.

Anjali Shah1

  • 1Department of Physical Medicine and Rehabilitation, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Mail Code 9055, Dallas, TX 75390-9055, USA. anjali.shah@utsouthwestern.edu

Physical Medicine and Rehabilitation Clinics of North America
|April 25, 2009
PubMed
Summary
This summary is machine-generated.

Multiple Sclerosis (MS) fatigue significantly impacts daily life. Further research is needed to understand its causes and effective treatments, including psychological interventions.

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Area of Science:

  • Neurology
  • Clinical Research

Background:

  • Fatigue is a significant and debilitating symptom in Multiple Sclerosis (MS).
  • It frequently interferes with daily activities, including home and vocational tasks.
  • The multifactorial nature of MS fatigue necessitates a comprehensive understanding of its contributing factors.

Purpose of the Study:

  • To highlight the severity and impact of fatigue in MS patients.
  • To emphasize the need for a clearer understanding of the etiology and pathophysiology of MS-related fatigue.
  • To recommend further research into various interventions, including pharmacologic, non-pharmacologic, and psychosocial approaches.

Main Methods:

  • Review of existing literature on MS-related fatigue.
  • Analysis of factors contributing to fatigue in MS.
  • Discussion of the need for randomized clinical trials.

Main Results:

  • MS-related fatigue is a severe problem impacting daily functioning.
  • Multiple contributing factors and potential confounders can exacerbate MS fatigue.
  • Current evidence on fatigue in MS is limited, with a notable reliance on self-perceived scores.

Conclusions:

  • A deeper understanding of MS fatigue etiology and pathophysiology is crucial.
  • Larger randomized clinical trials are required to evaluate interventions.
  • A multidisciplinary approach and further investigation into psychosocial interventions are recommended for managing MS fatigue.