Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Rheumatic Heart Disease IV: Nursing Management01:20

Rheumatic Heart Disease IV: Nursing Management

AssessmentA comprehensive assessment is essential in managing a patient with rheumatic heart disease (RHD). Begin with obtaining a detailed medical history, including recent streptococcal infections, a history of rheumatic fever, or previously diagnosed rheumatic heart disease. Assess the patient for symptoms such as fever, chest pain, widespread joint pain (arthralgia), tachycardia, pericardial friction rub, muffled heart sounds, heart murmurs, peripheral edema, subcutaneous nodules, and...
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
Fatigue01:21

Fatigue

Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective response...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same journal

Preface.

Physical medicine and rehabilitation clinics of North America·2026
Same journal

Pain Unbound: A Comprehensive Review.

Physical medicine and rehabilitation clinics of North America·2026
Same journal

Dual Frontiers Cancer and Palliative Care.

Physical medicine and rehabilitation clinics of North America·2026
Same journal

Pain Management Across Special Populations: Pediatrics, Geriatrics, and Pregnancy.

Physical medicine and rehabilitation clinics of North America·2026
Same journal

Healing from Within: Regenerative Medicine in Pain Therapy.

Physical medicine and rehabilitation clinics of North America·2026
Same journal

The Brain in Pain: Exploring Central Pain Disorders.

Physical medicine and rehabilitation clinics of North America·2026

Related Experiment Video

Updated: Jun 23, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Fatigue in rheumatologic diseases.

John C Pan1, David N Bressler

  • 1Department of Rehabilitation Medicine, Mount Sinai School of Medicine, Mount Sinai Medical Center, One Gustave Levy Place, Box 1240, New York, NY 10029, USA.

Physical Medicine and Rehabilitation Clinics of North America
|April 25, 2009
PubMed
Summary
This summary is machine-generated.

Fatigue is an under-addressed symptom in rheumatologic diseases. Understanding its complex causes is key to developing effective treatments, but more research is needed.

More Related Videos

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Related Experiment Videos

Last Updated: Jun 23, 2026

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease
04:24

Acupoint Application as a Traditional Chinese Medicine Treatment for Fatigue Associated with Chronic Obstructive Pulmonary Disease

Published on: September 5, 2025

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue
08:56

Evaluating the Role of Mitochondrial Function in Cancer-related Fatigue

Published on: May 17, 2018

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

Area of Science:

  • Rheumatology
  • Clinical Medicine

Background:

  • Fatigue is a prevalent yet under-reported symptom in rheumatologic diseases.
  • The multifactorial causes of fatigue in these conditions are not fully understood.
  • Addressing fatigue is crucial for effective patient management and treatment.

Purpose of the Study:

  • To highlight the significance of fatigue as an under-recognized symptom in rheumatologic diseases.
  • To emphasize the need for a comprehensive understanding of fatigue's multifactorial origins.
  • To underscore the necessity for targeted treatment strategies for fatigue.

Main Methods:

  • Literature review and synthesis of current understanding regarding fatigue in rheumatologic diseases.
  • Analysis of the challenges in deconstructing complex symptoms like fatigue.
  • Identification of research gaps in evaluating treatment efficacy.

Main Results:

  • Fatigue is frequently under-addressed by both patients and physicians in rheumatologic care.
  • The complex etiology of fatigue necessitates a multifactorial approach to treatment.
  • Current evidence for combined pharmacologic and non-pharmacologic strategies is limited.

Conclusions:

  • Recognizing and addressing fatigue is essential for improving patient outcomes in rheumatologic diseases.
  • Targeted treatment strategies require a deeper understanding of fatigue's underlying causes.
  • High-quality randomized controlled trials are needed to evaluate combined therapeutic approaches for fatigue.