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Ischaemia-modified albumin in dilated cardiomyopathy

Eftihia Sbarouni1, Panagiota Georgiadou, Maria Koutelou

  • 12nd Department of Cardiology, Onassis Cardiac Surgery Center, Athens 176 74, Greece. esbarouni@yahoo.gr

Annals of Clinical Biochemistry
|April 25, 2009
PubMed

Insights

Ischaemia-modified albumin (IMA) levels do not differ in stable dilated cardiomyopathy (DCM) patients compared to healthy individuals. However, IMA levels vary with heart failure severity in DCM patients.

Area of Science:

  • Cardiology
  • Biomarker Research
  • Heart Failure Studies

Background:

  • Myocardial necrosis biomarkers can elevate in chronic heart failure.
  • Investigating ischaemia-modified albumin (IMA) in compensated heart failure due to dilated cardiomyopathy (DCM).

Purpose of the Study:

  • To determine if IMA levels are elevated in patients with compensated heart failure from DCM.
  • To assess the relationship between IMA and disease severity in DCM.

Main Methods:

  • Studied 42 DCM patients and 42 age-matched healthy volunteers.
  • Assessed serum IMA levels using the albumin cobalt binding test.

Main Results:

  • No significant difference in IMA levels between DCM patients and controls (P = 0.11).
  • IMA levels significantly differed by New York Heart Association classification (P = 0.003).
  • IMA showed a negative correlation with left ventricular ejection fraction (r = -0.40, P = 0.014).

Conclusions:

  • IMA does not differ in clinically stable DCM patients versus controls.
  • IMA levels significantly correlate with the severity of DCM and heart failure.
Abstract

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