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The Contractile Ring

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...

The Contractile Ring

The Contractile Ring

Contractile rings are composed of microfilaments and are responsible for separating the daughter cells during cytokinesis. Contractile ring assembly proceeds along with other cell cycle events; however, very few mechanistic details are known about the timing and coordination of the contractile rings with the cell cycle.
A small GTPase, RhoA, controls the function and assembly of the contractile ring. RhoA belongs to the Ras superfamily of proteins. The activation of formins by RhoA promotes...

Cell Diversity

Cell Diversity

The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
Multicellular organisms...

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Related Experiment Video

Updated: Jun 23, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

Single cells (put a ring on it).

Benjamin A Wolfe¹, Michael Glotzer

¹Department of Molecular Genetics and Cell Biology, The University of Chicago, Chicago, Illinois 60637, USA.

Genes & Development

|April 25, 2009

Summary

This summary is machine-generated.

Researchers discovered two mechanisms that recruit Rho1 to the bud neck in yeast, ensuring proper cell division. This spatial regulation is crucial for cytokinesis, the final step in cell division.

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The Assembly and Application of 'Shear Rings': A Novel Endothelial Model for Orbital, Unidirectional and Periodic Fluid Flow and Shear Stress

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Area of Science:

Cell Biology
Molecular Biology
Genetics

Background:

Spatial and temporal control of the small GTPase RhoA is essential for eukaryotic cell division plane specification.
While RhoA activation post-chromosome segregation is understood, its precise localization to the division site remains unclear.

Purpose of the Study:

To investigate the mechanisms of Rho1 spatial regulation at the bud neck in Saccharomyces cerevisiae.
To identify how Rho1 is recruited to facilitate cytokinesis.

Main Methods:

Genetic analysis in Saccharomyces cerevisiae.
Investigating Rho1 recruitment to the bud neck.

Main Results:

Two genetically distinct mechanisms were identified for Rho1 recruitment to the bud neck.
These mechanisms ensure Rho1 concentration at the division site for proper cytokinesis.

Conclusions:

Rho1 localization to the bud neck is regulated by at least two separable genetic pathways.
These pathways are critical for the spatial control of cytokinesis in budding yeast.