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Alcohol consumption and kidney function in IgA glomerulonephritis.

Kati Kaartinen¹, Onni Niemela, Jaana Syrjanen

¹Medical School, University of Tampere, Tampere, Finland. kati.kaartinen@elisanet.fi

Nephron. Clinical Practice

|April 25, 2009

Summary

Moderate alcohol consumption may benefit IgA glomerulonephritis (IgAGN) patients. Light drinking in women and moderate drinking in men showed better kidney function, suggesting alcohol intake impacts IgAGN progression.

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Assessment of Kidney Function in Mouse Models of Glomerular Disease

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

Area of Science:

Nephrology
Internal Medicine
Epidemiology

Background:

IgA glomerulonephritis (IgAGN) has a variable prognosis with known risk factors for progression.
The impact of alcohol consumption on IgAGN progression has not been previously studied.
Some studies suggest moderate alcohol intake may protect kidney function.

Purpose of the Study:

To investigate the relationship between alcohol consumption and kidney function in IgA glomerulonephritis patients.
To determine if alcohol intake is associated with the progression of IgAGN.

Main Methods:

Cross-sectional study of 158 IgAGN patients with varying alcohol consumption levels (abstainers, light, moderate, heavy).
Alcohol intake assessed via interviews and serum carbohydrate-deficient transferrin levels.
Longitudinal data on renal function and disease progression analyzed for 117 patients.

Main Results:

Moderate alcohol drinkers exhibited the best kidney function.
Adjusted analyses revealed light and moderate alcohol consumption were associated with better kidney function.
Gender-specific analysis showed light drinking beneficial for women and moderate drinking for men.

Conclusions:

Moderate alcohol consumption may favorably impact IgA glomerulonephritis progression.
Light alcohol consumption in women and moderate consumption in men are linked to improved estimated glomerular filtration in IgAGN patients.