Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of Hemostasis01:24

Disorders of Hemostasis

Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Extrinsic and Intrinsic Pathways of Hemostasis01:20

Extrinsic and Intrinsic Pathways of Hemostasis

Blood clotting or coagulation involves extrinsic and intrinsic pathways, which ultimately merge into the common pathway, forming a fibrin clot.
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which forms a...
Coagulation01:09

Coagulation

The coagulation phase is a critical part of the body's process to prevent blood loss following injury to blood vessels. It involves chemical reactions that form a clot to seal the injured area. The clotting process begins shortly after injury, within 15-20 seconds for severe damage and 1-2 minutes for minor injuries.
During the coagulation phase, clotting factors, or procoagulants, play a vital role in initiating and progressing the coagulation cascade. This cascade is a series of reactions...
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Introduction to Hemostasis01:05

Introduction to Hemostasis

Hemostasis is a complex physiological process that prevents excessive bleeding when a blood vessel is injured. It's crucial for maintaining the integrity of the circulatory system, as it ensures that our blood remains fluid while still within the vascular network and yet clots to prevent blood loss upon vessel injury.
The three phases of hemostasis involve many clotting factors present in plasma and several substances released by platelets and injured tissue cells. It is a fast, localized, and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HIgh versus STAndard blood Pressure target in hypertensive high-risk patients undergoing elective major abdominal surgery: the HISTAP multicenter randomized clinical trial.

Intensive care medicine·2026
Same author

Is Early Vasopressor Administration Really Not Important in Septic Shock?

Annals of emergency medicine·2026
Same author

The role of hemoadsorption in septic shock: toward a personalized approach.

Critical care (London, England)·2026
Same author

Clinical Benefits of the Introduction of the ERAS Protocol in Thyroid Surgery: A Propensity Score Matching Analysis.

Journal of clinical medicine·2026
Same author

Relationship between norepinephrine dose and outcome in septic shock: a retrospective study.

Journal of anesthesia, analgesia and critical care·2026
Same author

The new SOFA for sepsis identification and mortality prediction: a multicenter cohort study.

Journal of intensive care·2026
Same journal

The evolution of nonoperating room anesthesia: navigating a new frontier.

Current opinion in anaesthesiology·2026
Same journal

Enhanced recovery pathways for patients with chronic pain: beyond standard protocols - a narrative review.

Current opinion in anaesthesiology·2026
Same journal

Novel technologies and innovations in postoperative follow-up after regional anesthesia.

Current opinion in anaesthesiology·2026
Same journal

Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications.

Current opinion in anaesthesiology·2026
Same journal

Retention in pain care and research: a narrative review focused on implanted medical devices.

Current opinion in anaesthesiology·2026
Same journal

Airway ultrasound in patients undergoing head and neck surgery.

Current opinion in anaesthesiology·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Link between coagulation abnormalities and microcirculatory dysfunction in critically ill patients.

Daniel De Backer1, Katia Donadello, Raphaël Favory

  • 1Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium. ddebacke@ulb.ac.be

Current Opinion in Anaesthesiology
|April 25, 2009
PubMed
Summary
This summary is machine-generated.

Coagulation may indirectly cause microcirculatory issues in sepsis and ischemia-reperfusion injury. While anticoagulants show benefits, these effects likely stem from broader actions, not just blood thinning.

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Related Experiment Videos

Last Updated: Jun 23, 2026

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care
14:28

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

Published on: May 10, 2024

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Area of Science:

  • Critical care medicine
  • Vascular biology
  • Hematology

Background:

  • Microvascular alterations are common in sepsis and ischemia-reperfusion injury.
  • These changes involve endothelial dysfunction and cell interactions.
  • Coagulation activation is observed, but microthrombosis is not the primary driver.

Purpose of the Study:

  • To review the role of coagulation in microcirculatory abnormalities.
  • To investigate if anticoagulants can improve microvascular perfusion.

Main Methods:

  • Literature review of studies on coagulation, microcirculation, and related conditions.
  • Analysis of evidence regarding the effects of anticoagulant agents on microvascular function.

Main Results:

  • Coagulation, inflammation, and endothelial interactions contribute to microvascular dysfunction.
  • Agents like activated protein C and antithrombin improve microcirculation, but likely via pleiotropic effects.
  • Evidence does not support using pure anticoagulants solely to enhance microvascular perfusion.

Conclusions:

  • Coagulation activation may indirectly contribute to microvascular dysfunction.
  • The interplay between coagulation, inflammation, and the endothelium is crucial.
  • Beneficial effects of certain agents are unlikely due to direct anticoagulation alone.