Related Experiment Video
Updated: Jun 23, 2026
08:53
Flow-sorting and Exome Sequencing of the Reed-Sternberg Cells of Classical Hodgkin Lymphoma
Published on: June 10, 2017
Salvage therapy for Hodgkin's lymphoma
Fahd Quddus1, James O Armitage
1Section of Hematology and Oncology, UNMC Oncology/Hematology Section, 987680 Nebraska Medical Center, University of Nebraska, Omaha, NE, USA. fquddus@unmc.edu
Cancer Journal (Sudbury, Mass.)
|April 25, 2009
Summary
Hodgkin
Area of Science:
- Oncology
- Hematology
Background:
- Hodgkin's lymphoma (HL) is a lymphoid malignancy impacting thousands annually in the US.
- Advances in radiation and chemotherapy yield >80% long-term survival for many HL patients.
- Relapsed HL after initial treatment presents a significant therapeutic challenge.
Purpose of the Study:
- To review current literature on salvage therapy for Hodgkin's lymphoma.
- To highlight challenges in treating relapsed HL after high-dose chemotherapy and autologous stem cell transplant.
- To underscore the need for novel therapeutic strategies.
Main Methods:
- Comprehensive literature review of salvage therapy for Hodgkin's lymphoma.
- Analysis of treatment outcomes for relapsed HL patients.
- Identification of gaps in current therapeutic options.
Main Results:
- Hodgkin's lymphoma has high survival rates with current therapies.
- Patients relapsing after salvage high-dose chemotherapy and autologous stem cell transplant have limited effective options.
- Novel therapeutic approaches are essential for refractory/relapsed HL.
Conclusions:
- While overall survival for Hodgkin's lymphoma is high, relapsed disease remains difficult to treat.
- Salvage therapy options for patients progressing after autologous stem cell transplant are limited.
- Further research and development of new therapies are crucial for improving outcomes in relapsed Hodgkin's lymphoma.
Related Concept Videos
01:22Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
01:21Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...