Related Experiment Video
Updated: Jun 23, 2026

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
Published on: April 23, 2021
Longitudinal cognitive performance in older adults with cardiovascular disease: evidence for improvement in heart
Kelly M Stanek1, John Gunstad, Robert H Paul
1Department of Psychology, Kent State University, Kent, Ohio 44242, USA. kstanek@kent.edu
Insights
Older adults with heart failure (HF) showed modest cognitive improvements over 12 months, unlike those with other cardiovascular diseases (CVD). This suggests cognitive function in HF may be modifiable, potentially linked to blood pressure control.
Area of Science:
- Neurology
- Cardiology
- Gerontology
Background:
- Cardiovascular disease (CVD), especially heart failure (HF), is linked to cognitive impairment in older adults.
- Longitudinal cognitive changes in CVD patients, particularly those with HF, remain under-researched.
Purpose of the Study:
- To prospectively evaluate cognitive function progression in older adults with HF compared to other CVDs.
- To identify potential factors influencing cognitive changes in this population.
Main Methods:
- Seventy-five older adults with CVD were assessed using Doppler echocardiogram and the Dementia Rating Scale (DRS) at baseline and 12 months.
- Cognitive function was measured globally and across specific domains like attention and executive function.
Main Results:
- Patients with HF demonstrated significant improvements in global cognitive function (DRS scores) over 12 months.
- Cognitive function remained stable in patients with other forms of CVD.
- Improvements in HF patients were noted in attention, initiation/perseveration, and conceptualization subscales.
Conclusions:
- Heart failure patients experienced modest cognitive gains, particularly in attention and executive functions, over a year.
- Higher baseline diastolic blood pressure correlated with improved cognitive performance in HF patients.
- These findings suggest cognitive impairment in HF may be reversible, with blood pressure management being a potential therapeutic target.
Background:
Cardiovascular disease (CVD) and particularly heart failure (HF) have been associated with cognitive impairment in cross-sectional studies, but it is unclear how cognitive impairment progresses over time in older adults with these conditions.
Objective:
The aim of this study was to prospectively examine cognitive function in patients with HF versus other forms of CVD.
Method:
Seventy-five older adults (aged 53-84 years) with CVD underwent Doppler echocardiogram to evaluate cardiac status and 2 administrations of the Dementia Rating Scale (DRS), a test of global cognitive functioning, 12 months apart.
Results:
Although DRS performance did not statistically differ between groups at either administration, a significant between-group difference in the rate of cognitive change emerged (lambda = 0.87; F = 10.50; P = .002; omega 2 = 0.11). Follow-up analyses revealed that patients with HF improved significantly on global DRS performance, whereas patients with other forms of CVD remained stable. More specifically, patients with HF showed improvement on subscales of attention, initiation/perseveration, and conceptualization. Exploratory analyses indicated that higher diastolic blood pressure at baseline was associated with improved DRS performance in patients with HF (r = 0.38; P = .02).
Conclusions:
Patients with HF exhibited modest cognitive improvements during 12 months, particularly in attention and executive functioning. Higher diastolic blood pressure at baseline was associated with improvement. These results suggest that cognitive impairment in patients with HF may be modifiable and that improved blood pressure control may be an important contributor to improved function. Further prospective studies are needed to replicate results and determine underlying mechanisms.
Related Concept Videos
Longitudinal Studies
Cognitive Development During Adulthood
Longitudinal Research
Heart Failure II: Pathophysiology
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be met...
Heart Failure III: Clinical Manifestations
