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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
Serum fluoride and sialic acid levels in osteosarcoma
1Department of Biochemistry, Pt B D Sharma University of Health Sciences, H No 1447, sector-1, Urban Estate, Rohtak, 124001, Haryana, India.
Biological Trace Element Research
|April 25, 2009
Summary
Elevated serum fluoride levels are linked to osteosarcoma, a rare bone cancer. This study found higher fluoride concentrations in osteosarcoma patients compared to those with other bone tumors or pain, suggesting fluoride
Area of Science:
- Oncology
- Biochemistry
- Environmental Health
Background:
- Osteosarcoma is a rare pediatric and young adult bone cancer.
- Etiological factors include radiation, genetics, chemicals, and viruses.
- The role of serum fluoride levels in osteosarcoma remains unclear.
Purpose of the Study:
- To investigate serum fluoride, sialic acid, calcium, phosphorus, and alkaline phosphatase in osteosarcoma patients.
- To compare these levels with age- and sex-matched controls (other bone tumors and musculoskeletal pain).
Main Methods:
- Serum samples from 25 osteosarcoma patients and 50 controls were analyzed.
- Fluoride levels were measured using Ion-Selective Electrode (ISE) method.
- Sialic acid was quantified using Warren's method.
Main Results:
- Mean serum fluoride concentration was significantly higher in osteosarcoma patients versus controls.
- Fluoride levels in patients with other bone tumors were also elevated compared to controls.
- Serum sialic acid was significantly elevated in both osteosarcoma and other bone tumor groups compared to controls.
Conclusions:
- Higher serum fluoride levels in osteosarcoma patients suggest a potential role for fluoride in the disease's etiology.
- Elevated sialic acid in both tumor groups indicates its potential as a biomarker for bone tumors.
