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Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...

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Related Experiment Video

Updated: Jun 23, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Granulocytic sarcoma.

J B Ghosh¹, Mahua Roy, Anirban Halder

¹Department of Pediatric Medicine, IPGME & R, Kolkata, India.

Indian Journal of Pediatrics

|April 25, 2009

Summary

This summary is machine-generated.

Gastrointestinal stromal tumors (GSTs) can be the initial sign of acute myeloid leukemia (AML), appearing months before diagnosis. This highlights the importance of considering hematologic malignancies in patients with these rare presentations.

Related Experiment Videos

Last Updated: Jun 23, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Area of Science:

Oncology
Hematology

Background:

Gastrointestinal stromal tumors (GSTs) are rare mesenchymal neoplasms.
Acute myeloid leukemia (AML) is a hematologic malignancy.

Observation:

Two cases are presented where GSTs were the sole initial clinical manifestation.
These presentations occurred months prior to the definitive diagnosis of AML.

Findings:

GSTs can precede the diagnosis of AML by several months.
GSTs may represent an extramedullary manifestation of AML.

Implications:

This association suggests a potential link between GSTs and AML.
Early recognition of GSTs in the context of AML may improve diagnostic timelines.
Further research is warranted to elucidate the underlying mechanisms of this association.