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Stem Cell Culture

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.

Embryonic Stem Cells

Embryonic Stem Cells

Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...

Induced Pluripotent Stem Cells

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...

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Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore called induced pluripotent stem...

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Related Experiment Video

Updated: Jun 23, 2026

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples

Reprogramming Induced Pluripotent Stem Cell Lines from Frozen Buffy Coat Samples

Published on: April 10, 2026

Stem cell through present and future.

Vijay K Sharma¹, Utpal K Singh, Rajniti Prasad

¹Dewsbury District Hospital, Dewbury, UK.

Indian Journal of Pediatrics

|April 25, 2009

Summary

This summary is machine-generated.

Stem cell transplantation (SCT) offers life-changing potential for children with genetic diseases. However, ongoing risks and emerging alternative therapies require careful evaluation of its use.

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Area of Science:

Pediatric Hematology/Oncology
Genetic Diseases
Regenerative Medicine

Background:

Stem cell transplantation (SCT) is a significant advancement for children with genetic disorders affecting blood or solid organs.
These conditions often lead to poor life expectancy or quality of life without intervention.

Purpose of the Study:

To review the current landscape of SCT for pediatric genetic diseases.
To assess the risk/benefit ratio in light of emerging alternative therapies.
To discuss transplant indications, outcomes, and future directions.

Main Methods:

Review of existing literature on stem cell transplantation for pediatric genetic diseases.
Analysis of current therapeutic advancements and alternative treatment options.
Evaluation of short-term risks and potential long-term toxicities associated with SCT.

Main Results:

SCT has transformed care for many children, but remains experimental with significant risks.
Alternative therapies like gene and enzyme treatments are rapidly emerging.
Long-term follow-up data is limited due to the novelty of the field.

Conclusions:

The appropriateness of SCT must be continually reassessed against evolving alternative treatments.
Further research is needed to understand long-term outcomes and optimize risk-benefit profiles.
The rapid pace of technological change complicates traditional randomized trial designs.