Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Teeth

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Individual Health Management (IHM) for Stress-A Randomised Controlled Trial (TALENT II Study).

Healthcare (Basel, Switzerland)·2025

Same author

A Five-Year Follow-Up Study on the Removal of Dental Amalgam Restorations (Bergen Amalgam Trial): Examining Potential Confounding Factors and Effect Modification.

Journal of oral rehabilitation·2025

Same author

[Preparedness on Assaults with Highly Toxic Substances in Public Space].

Gesundheitswesen (Bundesverband der Arzte des Offentlichen Gesundheitsdienstes (Germany))·2022

Same author

Mushroom Poisoning.

Deutsches Arzteblatt international·2021

Same author

Removal of dental amalgam restorations in patients with health complaints attributed to amalgam: A prospective cohort study.

Journal of oral rehabilitation·2020

Same author

Reducing antipsychotic drugs in stable patients with chronic schizophrenia or schizoaffective disorder: a randomized controlled pilot trial.

European archives of psychiatry and clinical neuroscience·2020

Same journal

Treatment preferences related to pulpectomy and prosthetic restorations among Lithuanian general dentists and prosthodontists.

Acta odontologica Scandinavica·2026

Same journal

Tissue response in hemisectioned primary mandibular second molars.

Acta odontologica Scandinavica·2026

Same journal

Exploring fulfillment of basic psychological needs in patients with dental anxiety: an investigation grounded in self-determination theory.

Acta odontologica Scandinavica·2026

Same journal

Relationship between dietary diversity and periodontitis: analysis of NHANES 2003-2014.

Acta odontologica Scandinavica·2026

Same journal

Associations between oral microbiome diversity and rheumatoid arthritis in U.S. adults: NHANES 2009-2012.

Acta odontologica Scandinavica·2026

Same journal

Complications of dermal filler treatments – a registry-based study from Finland.

Acta odontologica Scandinavica·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 23, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Does a specific dental amalgam syndrome exist? A comparative study.

Wolfgang Weidenhammer¹, Constanze Hausteiner, Thomas Zilker

¹Centre for Complementary Medicine Research, Internal Medicine II, Technical University, Munich, Germany. wolfgang.weidenhammer@lrz.tum.de

Acta Odontologica Scandinavica

|April 25, 2009

Summary

This summary is machine-generated.

This study found no strong evidence for a specific syndrome linked to dental amalgam. Health complaints attributed to amalgam fillings were similar in psychological distress to other environmental factors.

More Related Videos

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation

Published on: July 21, 2014

Related Experiment Videos

Last Updated: Jun 23, 2026

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Micro-dissection of Enamel Organ from Mandibular Incisor of Rats Exposed to Environmental Toxicants

Published on: March 29, 2018

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation

Shrinkage of Dental Composite in Simulated Cavity Measured with Digital Image Correlation

Published on: July 21, 2014

Area of Science:

Environmental Health
Toxicology
Psychosomatic Medicine

Background:

Dental amalgam is a widely used restorative material.
Concerns exist regarding potential health effects of mercury released from amalgam fillings.
Previous research has yielded conflicting results on amalgam's health impacts.

Purpose of the Study:

To investigate the existence of a specific syndrome of health problems attributed to dental amalgam.
To compare psychological distress and symptom profiles in patients reporting amalgam-related health issues versus those with other environmental concerns.

Main Methods:

Retrospective analysis of two patient databases: one from a clinical trial on amalgam removal and another from an environmental medicine outpatient unit.
Comparison of psychological distress, symptom intensity, and self-reported symptoms using the Symptom Check List, controlling for age, sex, and education.
Assessment of self-consciousness levels (private and public) and prevalence of mental versus somatic symptoms.

Main Results:

No statistically significant differences in overall psychological distress, symptom intensity, or number of symptoms between the amalgam and comparison groups after controlling for covariates.
Patients from the amalgam group reported similar levels of private and public self-consciousness to the population norm, while the comparison group showed significantly decreased values.
The amalgam group reported more mental symptoms, whereas the comparison group reported a higher prevalence of somatic symptoms.

Conclusions:

While some differences in symptomatology were observed, general psychological distress was comparable between groups.
The findings do not provide strong evidence for a distinct amalgam-specific syndrome.
Further research may be needed to elucidate the complex relationship between dental materials and health complaints.