Synthesis and characterization of hyperbranched poly(glycidol) modified with pH- and temperature-sensitive groups
Chie Kojima1, Kohei Yoshimura, Atsushi Harada
1Department of Applied Chemistry, Osaka Prefecture University, Osaka, Japan.
Abstract:
Hyperbranched poly(glycidol)s with varying degrees of polymerization were modified by reaction with succinic anhydride and isopropylamine to obtain novel pH- and thermosensitive polymers. These polymers exhibited phase transitions in response to decreasing pH and/or increasing temperature, depending on the degree of polymerization and the ratio of succinyl group to N-isopropylamide. It was possible to harvest a bioactive molecule, rose bengal, from solution using the phase transition of thermosensitive hyperbranched poly(glycidol).
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