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Imidazole binding sites in rabbit kidney and forebrain membranes
C A Hamilton1, M A Yakubu, E Jardine
1University Department of Medicine and Therapeutics, Stobhill General Hospital, Glasgow, Scotland.
Journal of Autonomic Pharmacology
|August 1, 1991
Abstract:
1. The binding of [3H]-clonidine, [3H]-idazoxan and [3H]-yohimbine to rabbit forebrain and kidney membranes was compared. 2. Yohimbine bound exclusively to adrenergic sites, idazoxan to non-adrenergic sites and clonidine to both non-adrenergic and adrenergic sites. 3. Differences were observed between the ligands not only in binding at adrenergic and non-adrenergic sites but also between the non-adrenergic binding of [3H]-clonidine and [3H]-idazoxan. 4. However, no tissue specific differences were found.