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The effects of selected probiotic strains on the development of eczema (the PandA study)

L Niers1, R Martín, G Rijkers

  • 1Department of Pediatrics, Wilhelmina Children's' Hospital, University Medical Center, Utrecht, the Netherlands.

Allergy
|April 28, 2009
PubMed

Insights

Probiotic supplementation with Bifidobacterium bifidum, Bifidobacterium lactis, and Lactococcus lactis reduced eczema incidence in high-risk infants. The preventive effect on eczema was observed within the first 3 months and sustained for 2 years.

Area of Science:

  • Microbiology and Immunology
  • Pediatric Allergy and Dermatology

Background:

  • Intestinal microbiota modulation via probiotics is a potential strategy for preventing allergic diseases.
  • High-risk infants (positive family history of allergy) were studied for primary prevention of allergic disease.

Purpose of the Study:

  • To investigate the efficacy of pre- and postnatal probiotic supplementation in preventing allergic disease in high-risk children.
  • To assess the impact of a specific probiotic mixture on eczema incidence and related immune markers.

Main Methods:

  • A double-blind, randomized, placebo-controlled trial was conducted.
  • Mothers of high-risk children received a probiotic mixture (Bifidobacterium bifidum, Bifidobacterium lactis, Lactococcus lactis) prenatally and their offspring for the first 12 months.
  • Parental reports and in vitro immune responses were monitored.

Main Results:

  • Eczema incidence was significantly lower in the probiotic group during the first 3 months (6/50 vs 15/52, P=0.035).
  • Eczema incidence became similar after 3 months, but cumulative incidence remained lower in the intervention group at 1 and 2 years.
  • The probiotic group showed increased Lactococcus lactis colonization and decreased IL-5 production at 3 months.

Conclusions:

  • This probiotic combination demonstrates a preventive effect on eczema in high-risk children.
  • The preventive effect is established early, within the first 3 months, and sustained for up to 2 years.
  • Probiotic-induced changes in Lc. lactis colonization and IL-5 production may contribute to eczema prevention.
Abstract

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