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Related Concept Videos

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation01:22

Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
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Related Experiment Video

Updated: Jun 23, 2026

Rapid Quantification of Oxidized and Reduced Forms of Glutathione Using Ortho -phthalaldehyde in Cultured Mammalian Cells In Vitro
03:35

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Published on: June 28, 2024

Glutathione: a key player in autoimmunity.

Carlo Perricone1, Caterina De Carolis, Roberto Perricone

  • 1Sapienza University of Rome, Unit of Rheumatology, Department of Clinic and Medical Therapy, Rome, Italy. carlo.perricone@gmail.com

Autoimmunity Reviews
|April 28, 2009
PubMed
Summary

Reactive oxygen species (ROS) contribute to oxidative stress in inflammatory diseases. Glutathione, a key antioxidant, plays a crucial role in modulating immune responses and may impact autoimmune conditions.

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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
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Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases
14:57

Spectrophotometric Screening for Potential Inhibitors of Cytosolic Glutathione S-Transferases

Published on: October 10, 2020

Area of Science:

  • Immunology
  • Biochemistry
  • Pathophysiology

Background:

  • Reactive oxygen species (ROS) are increasingly implicated in the pathophysiology of inflammatory and immunomediated diseases.
  • Sustained ROS production during chronic inflammation can overwhelm antioxidant defenses, leading to oxidative stress.
  • Antioxidant defense systems, particularly glutathione, are often deficient in patients with chronic degenerative and autoimmune diseases.

Purpose of the Study:

  • To review the role of glutathione in the immune system.
  • To explore the connection between glutathione concentrations and autoimmune pathological conditions.
  • To understand how oxidative stress influences inflammatory and immune responses.

Main Methods:

  • Literature review focusing on the interactions between glutathione and the immune system.
  • Analysis of studies investigating the role of reactive oxygen species (ROS) in inflammation.
  • Examination of research on antioxidant defense systems in chronic degenerative diseases.

Main Results:

  • Glutathione is a primary cellular antioxidant crucial for immune system function.
  • Glutathione can modulate immune responses, influencing inflammation.
  • Altered glutathione levels are potentially significant in autoimmune diseases driven by oxidative stress.

Conclusions:

  • Glutathione plays a multifaceted role in immune regulation and inflammation control.
  • Oxidative stress, influenced by glutathione status, is a key factor in many autoimmune diseases.
  • Further investigation into glutathione's role in autoimmunity is warranted.