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Myelin peptides in multiple sclerosis

L Grau-López1, D Raïch, C Ramo-Tello

  • 1Department of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain.

Autoimmunity Reviews
|April 28, 2009
PubMed

The development of specific therapies for organ-specific autoimmune diseases requires the identification of relevant immunogenic epitopes, recognized by both pathogenic T cells and autoantibodies. Here, we review the most relevant studies focused in the identification of peptides in multiple sclerosis (MS) and the distinct T cell reactivity induced in patients compared to controls. Only a few studies reported significant differences in terms of T cell reactivity to them. The current knowledge on this issue, and the diagnostic and therapeutic possibilities opened by the identification of pathogenic MS epitopes are discussed in this paper.

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