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Related Experiment Video

Updated: Jun 23, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

Proteomic toolbox for autoimmunity research.

Tianfu Wu1, Chandra Mohan

  • 1The Department of Internal Medicine (Rheumatology), University of Texas Southwestern Medical School, Dallas, TX 75390, USA. Tianfu.wu@utsouthwestern.edu

Autoimmunity Reviews
|April 28, 2009
PubMed
Summary
This summary is machine-generated.

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Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...

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Early biomarker discovery for autoimmune diseases is crucial. Proteomic analysis of body fluids offers a promising, non-invasive method for early diagnosis and treatment, utilizing advanced techniques.

Area of Science:

  • Immunology
  • Biochemistry
  • Medical Diagnostics

Background:

  • Autoimmune diseases are complex genetic conditions with severe consequences like end-organ damage.
  • Early diagnosis and treatment are vital due to the poorly understood nature and potential severity of these diseases.
  • Biomarker discovery is essential for improving patient outcomes in autoimmune conditions.

Purpose of the Study:

  • To review the application of proteomic analysis for early biomarker discovery in autoimmune diseases.
  • To summarize traditional and novel proteomic methods used in autoimmunity research.
  • To highlight the potential of non-invasive body fluid analysis for diagnosis.

Main Methods:

  • Review of various proteomic techniques including 2D-MS/MS, multi-dimensional HPLC-MS/MS, CE-MS/MS, SELDI-TOF-MS/MS, and iTRAQ.

Related Experiment Videos

Last Updated: Jun 23, 2026

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry
12:36

Single-cell Analysis of Immunophenotype and Cytokine Production in Peripheral Whole Blood via Mass Cytometry

Published on: June 26, 2018

  • Discussion of targeted antibody-based protein arrays.
  • Focus on proteomic analysis of body fluids as a non-invasive diagnostic tool.

    • Main Results:

    • Proteomics has significantly advanced the study of autoimmune diseases over the past decade.
    • Various proteomic methods have proven informative in understanding autoimmunity.
    • Body fluid proteomic analysis shows great potential for non-invasive early diagnosis.

    Conclusions:

    • Proteomic analysis is a powerful tool for autoimmune disease biomarker discovery.
    • Non-invasive methods like body fluid analysis are key for early diagnosis.
    • Continued application of advanced proteomic techniques will enhance autoimmunity research and clinical practice.