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Effectiveness of topically applied halofuginone in management of subglottic stenosis in rats
Eylem Ertug Ertuğrul1, I Engin Cekin, Hakan Cincik
1ENT Department, Güneydoğu Medical Center, Diyarbakir, Turkey. ertugrul@doctor.com
Objective:
The aim of the study is to ascertain the antifibrotic effect of topically applied halofuginone after acute subglottic injury.
Materials And Methods:
After standardized trauma to subglottic area, rats were divided into two groups: the study group that received treatment and the control group that did not. The subjects were treated with topical application of cottonoid soaked in 30 mg/dL halofuginone solution for 5 minutes after subglottic trauma. The larynx specimens were examined histopathologically by light microscopy to assess fibrosis, epithelialization, inflammation, and necrosis.
Results:
The fibrosis indexes of the treated group were significantly less than those of the control group (P < 0.05).
Conclusions:
Topically applied halofuginone hydrobromide decreases fibrosis/scar tissue formation secondary to experimentally induced acute subglottic trauma.
