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Updated: Jun 23, 2026

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
Published on: May 10, 2022
Polymorphisms in the interleukin-22 receptor alpha-1 gene are associated with severe chronic rhinosinusitis
Leandra Mfuna Endam1, Yohan Bossé, Abdelali Filali-Mouhim
1Department of Otolaryngology, Hôtel-Dieu Hospital, Montreal University, Montreal, PQ, Canada.
Rationale:
Stimulation of interleukin-22 receptor alpha-1 (IL22RA1) was reported to increase the innate immune responses in inflammatory diseases. Moreover, a reduced level of IL22RA1 was found in patients with recalcitrant CRS with nasal polyps.
Objective:
To explore association between single nucleotide polymorphisms (SNPs) in IL22RA1 and severe CRS.
Methods:
We extracted DNA from 206 cases with severe CRS and 196 postal code-matched controls. Twenty-three SNPs in the IL22RA1 gene were selected from the pooling-based genome-wide association study and from the CEU HapMap dataset and genotyped. PLINK software was used to determine association.
Results:
After Bonferroni correction, three SNPs (rs4292900 P(nom) = 0.0006, OR = 1.757; rs4648936 P(nom) = 0.0011, OR = 1.716; rs16829225 P(nom) = 0.0014, OR = 1.977) show significant differences in allelic frequencies between cases and controls.
Conclusion:
Polymorphisms in IL22RA1 are associated with severe CRS. Replication and functional studies are involved to better understand the mechanism by which these polymorphisms contribute to the pathogenesis of CRS.
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