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¹Department of Rheumatology & Clinical Immunology, University Medical Center Utrecht, Utrecht, the Netherlands. j.w.g.jacobs@umcutrecht.nl

Best Practice & Research. Clinical Rheumatology

|April 28, 2009

Summary

Local glucocorticoid injections can effectively treat soft-tissue lesions, whether related to inflammatory rheumatic diseases or not. This review examines injection therapy for these conditions and nerve compression syndromes.

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Area of Science:

Rheumatology
Orthopedics
Sports Medicine

Background:

Inflammation or irritation of periarticular soft tissues (tendons, bursae, ligaments, etc.) is common in rheumatic diseases but also occurs independently.
These soft-tissue lesions can cause significant pain and functional impairment.
Limited literature exists on the efficacy of local injection therapies for these conditions.

Purpose of the Study:

To review the current evidence and clinical practice of local glucocorticoid injection therapy for periarticular soft-tissue lesions.
To discuss the application of local injection therapy for nerve compression syndromes.
To provide a comprehensive overview of injection treatments for common musculoskeletal complaints.

Main Methods:

Literature review of studies investigating local glucocorticoid injections for soft-tissue lesions and nerve compression syndromes.
Analysis of evidence regarding the benefits and limitations of this therapeutic approach.
Synthesis of information on primary and secondary soft-tissue lesions.

Main Results:

Local glucocorticoid injections are frequently beneficial for both primary and secondary soft-tissue lesions.
Evidence supporting efficacy is limited but suggests a positive role for injections.
The review covers various soft-tissue structures and nerve entrapments.

Conclusions:

Local glucocorticoid injection is a valuable treatment option for periarticular soft-tissue inflammation and irritation.
Further research is needed to strengthen the evidence base for injection therapies.
This approach offers a potential solution for patients with or without underlying rheumatic diseases and for nerve compression issues.