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Safety of hypercapnic challenge: cardiovascular and neurologic considerations
D R Gitelman1, I Prohovnik, T K Tatemichi
1Brain Imaging Division, New York State Psychiatric Institute, New York.
Abstract:
The hemodynamic, cerebrovascular, and neurologic effects of hypercapnia with 4% and 6% CO2 were retrospectively reviewed in 217 patients referred for regional CBF (rCBF) procedures. Inhalation of CO2 significantly increased rCBF, blood pressure, and pulse from baseline. The findings suggest a higher incidence of side effects with 6% CO2 concentration and an equivalent vasoreactivity to 4%. We recommend the use of 4% CO2 for hypercapnic stimulation, and present safety guidelines for its use.