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Lori Lavigne-Brunette1, Marc-André Joly, Susan Kelly

  • 1Health Canada, Health Products and Foods Branch, Biologics and Genetic Therapies Directorate, Centre for Biologics Research, Cellular and Molecular Biology Division, AL 2201E Sir FG Banting Research Laboratories, Ottawa, ON, Canada.

Research in Veterinary Science
|April 28, 2009
PubMed

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...