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Updated: Jun 23, 2026
07:09
Isolation of Adipose Tissue Immune Cells
Published on: May 22, 2013
[Inflammation, adipokines and obesity].
1Service de nutrition, pôle d'endocrinologie, hôpital de la Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, U872 (équipe 7), Inserm, centre de recherche des Cordeliers, université Pierre-et-Marie-Curie Paris-6, 75006 Paris, France. karine.clement@psl.aphp.fr
La Revue De Medecine Interne
|April 28, 2009
Summary
Obesity causes chronic inflammation due to rising adipokines and macrophage infiltration. Weight loss significantly reduces these inflammatory markers, improving obesity-related health risks.
Area of Science:
- Immunology
- Metabolic Disorders
- Obesity Research
Background:
- Obesity is linked to a chronic, low-grade inflammatory state.
- This inflammation involves elevated systemic adipokines and macrophage infiltration in adipose tissue.
- These factors contribute to understanding obesity's pathophysiology and associated complications.
Purpose of the Study:
- To elucidate the inflammatory mechanisms in obesity.
- To investigate the impact of weight reduction on obesity-induced inflammation.
- To understand the relationship between inflammation and obesity-related metabolic, cardiovascular, and hepatic risks.
Main Methods:
- Analysis of systemic adipokine levels in obese subjects.
- Assessment of macrophage infiltration in adipose tissue.
- Monitoring of inflammatory gene profiles in adipose tissue following weight reduction.
Main Results:
- Obese subjects exhibit a chronic rise in systemic adipokines and adipose tissue macrophage infiltration.
- Weight reduction, even moderate, significantly decreases circulating inflammatory markers.
- Adipose tissue inflammatory gene expression is modulated by weight loss.
Conclusions:
- The inflammatory state in obesity is characterized by adipokines and macrophage infiltration.
- Weight loss is an effective strategy to reduce obesity-related inflammation.
- Reducing inflammation through weight loss mitigates metabolic, cardiovascular, and hepatic risks associated with obesity.
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