Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document any history...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of fluid...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized, placebo-controlled, dose-escalation phase I/II multicenter trial of low-dose cidofovir for BK polyomavirus nephropathy.

Transplant infectious disease : an official journal of the Transplantation Society·2024
Same author

Novel indications for referral and care for simultaneous liver kidney transplant recipients.

Current opinion in nephrology and hypertension·2024
Same author

A multicenter prospective study to define the natural history of BK viral infections in kidney transplantation.

Transplant infectious disease : an official journal of the Transplantation Society·2024
Same author

Understanding Delayed Graft Function to Improve Organ Utilization and Patient Outcomes: Report of a Scientific Workshop Sponsored by the National Kidney Foundation.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2023
Same author

Survey of Salary and Job Satisfaction of Transplant Nephrologists in the United States.

Clinical journal of the American Society of Nephrology : CJASN·2022
Same author

Existing Transplant Nephrology Compensation Models and Opportunities for Equitable Pay.

Clinical journal of the American Society of Nephrology : CJASN·2022

Related Experiment Video

Updated: Jun 23, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
11:54

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

Published on: July 13, 2019

Polyomavirus nephropathy: a current perspective and clinical considerations.

Alexander C Wiseman1

  • 1Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Aurora, CO 80045, USA. alexander.wiseman@ucdenver.edu

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|April 28, 2009
PubMed
Summary

Human polyomaviruses (BK virus and JC virus) are now key considerations for kidney transplant recipients. This review details advances in understanding and managing polyomavirus-associated nephropathy (PVAN) despite ongoing challenges.

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

Related Experiment Videos

Last Updated: Jun 23, 2026

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry
11:54

Measurement of BK-polyomavirus Non-Coding Control Region Driven Transcriptional Activity Via Flow Cytometry

Published on: July 13, 2019

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

Area of Science:

  • Nephrology
  • Virology
  • Immunology

Background:

  • Human polyomaviruses, specifically BK virus and JC virus, are increasingly relevant in kidney transplant recipients.
  • Polyomavirus-associated nephropathy (PVAN) emerged with potent immunosuppression, the primary risk factor for viral reactivation.
  • Despite progress, understanding PVAN risk factors and effective antiviral treatments remains limited.

Purpose of the Study:

  • To review advancements in the understanding and management of PVAN over the past decade.
  • To highlight emerging data relevant to clinical decision-making for PVAN.
  • To address common clinical considerations faced by healthcare providers.

Main Methods:

  • This is a review article, summarizing existing literature and clinical data.
  • Focuses on advances in pathogenesis, clinical presentation, and management strategies.
  • Highlights emerging data and clinical considerations.

Main Results:

  • Significant progress has been made in preventing and controlling viral-induced interstitial nephritis.
  • Clinical decision-making for PVAN is now routine.
  • Enhanced ability to manage PVAN despite knowledge gaps.

Conclusions:

  • PVAN is a critical clinical entity in kidney transplantation.
  • Management has improved, but further research on risk factors and antiviral therapies is needed.
  • Clinicians face evolving challenges in PVAN understanding and treatment.