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Updated: Jun 23, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
2-(substituted phenyl)amino analogs of 1-methoxyspirobrassinol methyl ether: synthesis and anticancer activity
Peter Kutschy1, Aneta Salayová, Zuzana Curillová
1Department of Organic Chemistry, Institute of Chemical Sciences, Faculty of Science, P.J. Safárik University, Moyzesova 11, 040 01 Kosice, Slovak Republic. peter.kutschy@upjs.sk
Abstract:
New analogs of indole phytoalexin 1-methoxyspirobrassinol methyl ether have been designed by replacement of its 2-methoxy group with 2-(substituted phenyl)amino group. Synthesized by spirocyclization methodology, trans- and cis-diastereoisomers of target compounds were isolated and evaluated as potential anticancer and antimicrobial agents. Their molecular geometries were refined by ab initio minimizations. Pharmacophore modeling and QSAR studies were performed in order to correlate their molecular structure and biological activity.
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