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Drug-eluting bioabsorbable stents - an in vitro study.
J Mikkonen1, I Uurto, T Isotalo
1Institute of Biomaterials, Tampere University of Technology, Tampere 33101, Finland. joonas.mikkonen@bioretec.com
Acta Biomaterialia
|April 28, 2009
Summary
This study evaluated drug elution from novel bioabsorbable stents using four drugs. Results show drug concentration and hydrophilicity significantly influence elution, with sustained release achieved for all tested compounds.
Area of Science:
- Biomaterials Science
- Pharmacology
- Polymer Chemistry
Background:
- Drug-eluting stents (DES) are crucial in preventing restenosis after angioplasty.
- Bioabsorbable stents offer advantages over permanent metallic stents, but their drug elution characteristics require thorough investigation.
- Optimizing drug release profiles from bioabsorbable scaffolds is key to maximizing therapeutic efficacy and minimizing adverse events.
Purpose of the Study:
- To investigate the in vitro drug elution properties of novel bioabsorbable stents.
- To evaluate the impact of different drugs (dexamethasone, indomethacin, simvastatin, ciprofloxacin), drug concentrations, and gamma sterilization on elution kinetics.
- To understand the relationship between drug hydrophobicity and elution behavior from poly-lactic acid stents.
Main Methods:
- Braided poly-lactic acid (96l/4d) stents were coated with bioabsorbable polymer and drug solutions.
- Drug elution was measured in vitro using sodium-phosphate-buffered saline at 37°C and pH 7.4.
- Eluted drug concentrations were quantified using ultraviolet spectrometry, with variations for non-sterile and gamma-sterilized stents.
Main Results:
- All four drugs (dexamethasone, indomethacin, simvastatin, ciprofloxacin) exhibited sustained elution profiles.
- Higher drug loading generally resulted in faster elution and a more hydrophilic elution profile.
- Gamma sterilization slightly decreased elution rates for dexamethasone, indomethacin, and ciprofloxacin, but slightly increased it for ciprofloxacin, modifying elution profiles for three of the drugs.
Conclusions:
- Drug concentration and hydrophilicity are critical factors determining elution profiles from bioabsorbable stents.
- Sustained drug release was successfully achieved for all tested compounds, indicating potential for therapeutic applications.
- Gamma sterilization has a variable effect on drug elution kinetics, necessitating careful consideration during stent manufacturing and processing.
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01:16Methods for Studying Drug Absorption: In vitro
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01:09Methods for Studying Drug Absorption: In situ
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